We invite your proposals for collaborative research on the following technologies for oligonucleotide drug discovery.
Technologies to obtain ligands for the specific tissue delivery of oligonucleotide therapeutics
- Applying phage display, ribosomal display or other methods to find peptides including cyclic peptides that bind to specific cell membrane proteins
- Identifying low molecular weight proteins that bind to specific cell membrane proteins e.g. VHH, low molecular weight protein scaffolds
Quantification of oligonucleotide concentrations in biological samples
- Developing sensitive and simple assays for oligonucleotide amounts in plasma and tissues
Monitoring the tissue and subcellular distribution of oligonucleotide therapeutics
- Offering detection methods related to single molecule intracellular imaging
- Utilizing immunohistological methods such as anti-oligonucleotide antibodies, in situ hybridization, etc.
Other drug discovery technologies related to oligonucleotide therapeutics
Pulmonary inhalation devices for animal experiments
- Improving and developing devices including nebulizer to reduce loss of administered substances